For basic inquiries into the dynamics and structure of matter, space, and time, physicists seek the simplest kinds of interactions at the highest possible energies. These typically entail particle energies of many GeV, and interactions of the simplest kinds of particles: leptons (e.g. electrons and positrons) and quarks for the matter, or photons and gluons for the field quanta. Since isolated quarks are experimentally unavailable due to color confinement, the simplest available experiments involve the interactions of, first, leptons with each other, and second, of leptons with nucleons, which are composed of quarks and gluons. To study the collisions of quarks with each other, scientists resort to collisions of nucleons, which at high energy may be usefully considered as essentially 2-body interactions of the quarks and gluons of which they are composed. This elementary particle physicists tend to use machines creating beams of electrons, positrons, protons, and antiprotons, interacting with each other or with the simplest nuclei (e.g., hydrogen or deuterium) at the highest possible energies, generally hundreds of GeV or more.
The largest and highest-energy particle accelerator used for elementary particle physics is the Large Hadron Collider (LHC) at CERN, operating since 2009.[13]